GWAS-related meQTLs across different cancer types

We identified 2,214,458 meQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).



e.g., "BLCA"
e.g., "rs10000012"
e.g., "CTBP1"
e.g., "cg02980000"
Cancer type
QTL type
tagSNP
LD
SNP ID
SNP position (hg19)
alleles
probe
Gene position (hg19)
Gene
Beta
t-stat
r
p-value
Traits
BLCA cis rs11951515 0.508 rs10059993 chr5:43598352 A/G cg20545087 chr5:43514988 C5orf34 -0.45 -6.56 -0.32 1.73E-10 Metabolite levels (X-11787);
BLCA cis rs11630290 0.592 rs1017531 chr15:64158650 G/A cg12036633 chr15:63758958 NA 0.54 7.38 0.35 9.95E-13 Iris characteristics;
BLCA cis rs9309473 1 rs10187192 chr2:73713500 T/C cg20560298 chr2:73613845 ALMS1 -0.67 -8.74 -0.41 7.45E-17 Metabolite levels;
BLCA cis rs10267417 0.603 rs10228558 chr7:19911915 A/G cg05791153 chr7:19748676 TWISTNB 0.55 6.52 0.32 2.18E-10 Night sleep phenotypes;
BLCA cis rs7100689 0.784 rs10749562 chr10:82108253 G/T cg00277334 chr10:82204260 NA -0.47 -7.19 -0.35 3.45E-12 Post bronchodilator FEV1;
BLCA cis rs523522 0.962 rs10849758 chr12:120971149 C/T cg27279351 chr12:120934652 DYNLL1 0.7 10.36 0.47 2.51E-22 High light scatter reticulocyte count;
BLCA cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg18404041 chr3:52824283 ITIH1 -0.38 -7.43 -0.36 7.04E-13 Bipolar disorder;
BLCA cis rs7945705 0.902 rs11042152 chr11:9020987 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.27 7.2 0.35 3.34E-12 Hemoglobin concentration;
BLCA cis rs977987 0.778 rs1109341 chr16:75445605 G/A cg03315344 chr16:75512273 CHST6 0.4 8.98 0.42 1.28E-17 Dupuytren's disease;
BLCA cis rs10861342 1 rs11112380 chr12:105526695 C/T cg23923672 chr12:105501055 KIAA1033 0.68 6.21 0.3 1.36E-9 IgG glycosylation;
BLCA cis rs2204008 0.837 rs11168334 chr12:37961768 A/G cg13010199 chr12:38710504 ALG10B 0.61 9.97 0.46 5.77E-21 Bladder cancer;
BLCA cis rs10883723 0.773 rs11191303 chr10:104255158 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.72 12.35 0.54 1.13E-29 Allergic disease (asthma, hay fever or eczema);
BLCA cis rs2153535 0.58 rs1119690 chr6:8460660 G/A cg07606381 chr6:8435919 SLC35B3 0.83 14.14 0.59 9.27E-37 Motion sickness;
BLCA cis rs752010 0.695 rs11210509 chr1:42109311 A/G cg06885757 chr1:42089581 HIVEP3 0.34 7.77 0.37 7.21E-14 Lupus nephritis in systemic lupus erythematosus;
BLCA cis rs1707322 1 rs11211243 chr1:46455433 G/C cg03146154 chr1:46216737 IPP 0.43 6.19 0.3 1.6E-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction);